Endlicher 2009 Acta Medica (Hradec Kralove): Difference between revisions
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|title=Endlicher R, Krivรกkovรก P, Lotkova H, Milerovรก M, Drahota Z, Cervinkovรก Z (2009) Tissue specific sensitivity of mitochondrial permeability transition pore to Ca<sup>2+</sup> ions. Acta Medica (Hradec Kralove) 52:69-72. | |title=Endlicher R, Krivรกkovรก P, Lotkova H, Milerovรก M, Drahota Z, Cervinkovรก Z (2009) Tissue specific sensitivity of mitochondrial permeability transition pore to Ca<sup>2+</sup> ions. Acta Medica (Hradec Kralove) 52:69-72. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/19777870 PMID: 19777870 Open Access] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/19777870 PMID: 19777870 Open Access] | ||
|authors=Endlicher | |authors=Endlicher Rene, Stankova Pavla, Lotkova Halka, Milerova Marie, Drahota Zdenek, Cervinkova Zuzana | ||
|year=2009 | |year=2009 | ||
|journal=Acta Medica (Hradec Kralove) | |journal=Acta Medica (Hradec Kralove) |
Latest revision as of 11:08, 18 March 2020
Endlicher R, Krivรกkovรก P, Lotkova H, Milerovรก M, Drahota Z, Cervinkovรก Z (2009) Tissue specific sensitivity of mitochondrial permeability transition pore to Ca2+ ions. Acta Medica (Hradec Kralove) 52:69-72. |
Endlicher Rene, Stankova Pavla, Lotkova Halka, Milerova Marie, Drahota Zdenek, Cervinkova Zuzana (2009) Acta Medica (Hradec Kralove)
Abstract: Ca(2+)-induced opening of the mitochondrial permeability transition pore (MPTP) is involved in induction of apoptotic and necrotic processes. We studied sensitivity of MPTP to calcium using the model of Ca(2+)-induced, cyclosporine A-sensitive mitochondrial swelling. Presented data indicate that the extent of mitochondrial swelling (dA520/4 min) induced by addition of 25 microM Ca2+ is seven-fold higher in liver than in heart mitochondria (0.564 +/- 0.08/0.077 +/- 0.01). The extent of swelling induced by 100 microM Ca2+ was in liver tree times higher than in heart mitochondria (0.508 +/- 0.05/ 0.173 +/- 0.02). Cyclosporine A sensitivity showed that opening of the MPTP is involved. We may thus conclude that especially at low Ca2+ concentration heart mitochondria are more resistant to damaging effect of Ca2+ than liver mitochondria. These finding thus support hypothesis that there exist tissue specific strategies of cell protection against induction of the apoptotic and necrotic processes. โข Keywords: Mitochondria, MPTP, Swelling, Cell death, Apoptosis, Necrosis
โข O2k-Network Lab: CZ Hradec Kralove Cervinkova Z
Labels:
Pathology: Other
Stress:Cell death, Permeability transition
Organism: Rat
Tissue;cell: Heart, Liver
Preparation: Isolated mitochondria