E-L net ET capacity: Difference between revisions

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E-L net ET capacity

Description

The Free ET-capacity, ≈E, is the ET capacity corrected for LEAK respiration, ≈E = E-L. ≈E is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the free ET capacity, ≈E, and LEAK respiration, L_P, compensating for proton leaks, slip and cation cycling: E = ≈E+L_P (see free OXPHOS capacity).

Abbreviation: ≈E

Reference: Gnaiger 2014 MitoPathways

MitoPedia concepts: Respiratory state, Recommended

MitoPedia topics: EAGLE

Communicated by Gnaiger E 2014-09-21, edited 2015-01-19.

The Blue Book 2014: Fig. 2.4.

Coupling control states for ≈E

» Respiratory state

Reference state, Z_X: ET capacity, E = E´-ROX
Background state, Y_X: LEAK respiration, L = L´-ROX
Metabolic control variable, X=Z_X-Y_X: Scope of uncoupler stimulation, Free ET-capacity, ≈E = E-L

Flux control factor

» Flux control factor, FCF

Coupling control factor, 1-Y_X/Z_X: E-L coupling control factor, ET-pathway coupling efficiency: j_≈E = ≈E/E =(E-L)/E = 1-L/E

Compare

mt-Preparations Free OXPHOS capacity, ≈P = P-L
Intact cells Free ROUTINE activity, ≈R = R-L

@@ Line 1: / Line 1: @@
 {{MitoPedia
 |abbr=''≈E''
-|description=[[Image:E-L.jpg|50 px|Free ETS capacity]] The '''free ETS capacity''', ''≈E'', is the [[ETS capacity]] corrected for [[LEAK respiration]], ''≈E'' = ''E-L''. ''≈E'' is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ETS state, therefore, is partitioned into the free ETS capacity, ''≈E'', and LEAK respiration, ''L<sub>P</sub>'', compensating for proton leaks, slip and cation cycling: ''E'' = ''≈E''+''L<sub>P</sub>'' (see [[free OXPHOS capacity]]).
+|description=[[Image:E-L.jpg|50 px|Free ET-capacity]] The '''Free ET-capacity''', ''≈E'', is the [[ET capacity]] corrected for [[LEAK respiration]], ''≈E'' = ''E-L''. ''≈E'' is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the free ET capacity, ''≈E'', and LEAK respiration, ''L<sub>P</sub>'', compensating for proton leaks, slip and cation cycling: ''E'' = ''≈E''+''L<sub>P</sub>'' (see [[free OXPHOS capacity]]).
 |info=[[Gnaiger 2014 MitoPathways]]
 }}
@@ Line 15: / Line 15: @@
 == Coupling control states for ''≈E'' ==
 ::» [[Respiratory state]]
-* [[Reference state]], ''Z<sub>X</sub>'': [[Image:E.jpg|link=ETS capacity|ETS capacity]] [[ETS capacity]], ''E'' = ''E´''-ROX
+* [[Reference state]], ''Z<sub>X</sub>'': [[Image:E.jpg|link=ET capacity|ET capacity]] [[ET capacity]], ''E'' = ''E´''-ROX
 * [[Background state]], ''Y<sub>X</sub>'': [[Image:L.jpg|link=LEAK respiration|LEAK]] [[LEAK respiration]], ''L'' = ''L´''-ROX
-* [[Metabolic control variable]], ''X=Z<sub>X</sub>-Y<sub>X</sub>'': [[Image:E-L.jpg|50 px|link=Free ETS capacity |Free ETS capacity]] Scope of uncoupler stimulation, [[free ETS capacity]], ''≈E'' = ''E-L''
+* [[Metabolic control variable]], ''X=Z<sub>X</sub>-Y<sub>X</sub>'': [[Image:E-L.jpg|50 px|link=Free ET-capacity |Free ET-capacity]] Scope of uncoupler stimulation, [[Free ET-capacity]], ''≈E'' = ''E-L''
 == Flux control factor ==
 ::» [[Flux control factor]], ''FCF''
-* [[Coupling control factor]], 1-''Y<sub>X</sub>/Z<sub>X</sub>'': [[Image:j--E.jpg|50 px|link=ETS coupling efficiency |ETS coupling efficiency]] ''E-L'' coupling control factor, [[ETS coupling efficiency]]: ''j<sub>≈E</sub>'' = ''≈E/E'' =(''E-L'')/''E'' = 1-''L/E''
+* [[Coupling control factor]], 1-''Y<sub>X</sub>/Z<sub>X</sub>'': [[Image:j--E.jpg|50 px|link=ET-pathway coupling efficiency |ET-pathway coupling efficiency]] ''E-L'' coupling control factor, [[ET-pathway coupling efficiency]]: ''j<sub>≈E</sub>'' = ''≈E/E'' =(''E-L'')/''E'' = 1-''L/E''