About Oroboros

                

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Mitochondria and cell research

O2k: O2k-FluoRespirometer

High-Resolution FluoRespirometry (HRFR)

O2k-Network

O2k-Concept

Oroboros Instruments

Oroboros Instruments distributes the gold standard O2k-technology for high-resolution respirometry - HRR - world-wide. The Oroboros Company is a scientifically oriented organization, with emphasis on continuous innovation. The extension of the Oroboros O2k to the O2k-FluoRespirometer sets a new standard. Its modular design provides the flexibility for add-on O2k-Modules (see Oroboros O2k-Catalogue). The O2k is established internationally, with »4695 O2k-Publications in the scientific literature covering areas ranging from fundamental bioenergetics to the analysis of mitochondrial and metabolic diseases, advancing the rapidly growing field of preventive mitochondrial medicine. The Oroboros science team actively participates in science and research (see: publications). Moreover, the Oroboros O2k-Laboratory frequently host international researchers (visiting scientists). Oroboros Instruments organizes international O2k-Workshops on a regular basis. The O2k-Network includes and connects 762 reference laboratories worldwide. The NextGen-O2k extends HRR to include a Q-redox sensor and PhotoBiology module.

Oroboros O2k

Oroboros O2k represents the unique concept of the O2k-system for high-resolution respirometry and fluorometry (HRFR). Our flagship is the O2k-FluoRespirometer for mitochondria and cell research. Considering mitochondria as the powerhouses of the cell, the O2k introduced the concept of cell ergometry. Explore the power of life with the O2k. Are your cells MitoFit?

The O2k is applied world-wide in areas ranging from fundamental bioenergetics to the analysis of mitochondrial and metabolic diseases, advancing the rapidly growing field of preventive mitochondrial medicine. Mitochondrial fitness needs to be monitored in a variety of age-related health risks, including cardiovascular and degenerative diseases, such as type 2 diabetes, neurodegenerative diseases (Alzheimer’s, Parkinson’s, Huntington’s), and several types of cancer.

Oroboros MitoFit Laboratory

The Oroboros O2k is based on a radically different systems approach to the polarographic measurement of oxygen dynamics. HRFR rests on several tightly connected instrumental features and concepts integrated with the DatLab software, providing real-time display of oxygen concentration and respiration (oxygen flux) and fluorometric signals. The mechanics, critical selection of materials, and state-of-the-art electronics provide the basis of the signal stability of an optimized polarographic oxygen sensor and pre-calibrated fluorescence sensors (new' in O2k-Series H) in an electronically controlled thermal environment with high temperature stability. Calibrations and instrumental controls follow standard operating procedures, with highly automatic real-time analysis by the DatLab software. Scientific support is complementary to the Oroboros O2k approach.

Cell ergometry

• » Cell ergometry is a concept complete with elaborated protocols, to get started and gain competence in the expanding field of bioenergetics: » Blue Book 2014 - » O2k-Protocols.
• » Explore cell respiration and key mitochondrial functions: » HRFR.
• » Introductory courses and advanced training: » Oroboros Events.

» WorldWide distribution

Top 10 reasons for the Oroboros Ecosystem → innovation → dissemination → mitochondrial services → networking                     Advance bioenergetics to mitochondrial and cell physiology with the award-winning Oroboros O2k Long-term experience in high-resolution respirometry, HRR: >1,100 O2k sold Meet the experts at the outstanding O2k-Workshops on HRR Browse through 4695 O2k-Publications Join the world-wide O2k-Network The O2k-technology represents innovation, optimization, and continuous development Fair prices - low running costs Quality instead of empty advertisements Gentle Science - cooperation and corporate social responsibility Quality management and committment to reproducibility with the O2k

Oroboros projects Oroboros Instruments participates in HORIZON 2020 funded Marie Skłodowska-Curie projects TRACT and TRANSMIT: Horizon2020 COST ACTION CA15203 MitoEAGLE K-Regio MitoFit 762 O2k-Network Labs globally connected by High-Resolution O2k-FluoRespirometry » With Cuba, Israel, Mexico and Malaysia, the O2k is now applied in 49 countries. In the artwork "First Fruits of the Earth Offered to Saturn" at the Palazzo Vecchio, Saturn (Cronus in Greek mythology) is holding the Ouroboros in the hand, symbolizing the eternal cycle of renewal and the interconnectedness of beginning and end.  » Oroboros pictures of the month

4695 O2k-Publications in the MiPMap » Recent O2k-Publications Did you know: You can search for pathological states-such as cancer-, where 356 references are listed. Davis BN, Yen R, Prasad V, Truskey GA (2019) Oxygen consumption in human, tissue-engineered myobundles during basal and electrical stimulation conditions. APL Bioeng 3:026103. - »Bioblast link« Havird JC et al (2019) Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function? Mitochondrion 49:1-11. - »Bioblast link« Christian AR, Losantos-Ramos K, Marcelino G, Daniela F, Jorge S (2019) NADH-linked mitochondrial respiration in the developing mouse brain is sex-, age- and tissue-dependent. Respir Physiol Neurobiol 266:156-62. - »Bioblast link« The World as a Laboratory - science and adventure Gnaiger et al (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34. - »Bioblast link« Oroboros Events IOC137 Innsbruck, AT, 2018 Dec 10-12

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