Chandel 2021 Cold Spring Harb Perspect Biol

Chandel NS (2021) Mitochondria. Cold Spring Harb Perspect Biol 13:a040543. doi: 10.1101/cshperspect.a040543

» PMID: 33649187

Chandel NS (2021) Cold Spring Harb Perspect Biol

Abstract:

• Bioblast editor: Gnaiger E

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Correction: FADH₂ and S-pathway

• Complex II ambiguities

File:Chandel 2021 Cold Spring Harb Perspect Biol 1 CORRECTION.png

A commonly found error on FADH₂ in the S-pathway requires correction. For clarification, see page 48 in Gnaiger (2020)

• Quote (p 48): "The substrate of CII is succinate, which is oxidized forming fumarate while reducing flavin adenine dinucleotide FAD to FADH₂, with further electron transfer to the quinone pool. Whereas reduced NADH is a substrate of Complex I linked to dehydrogenases of the TCA cycle and mt-matrix upstream of CI, reduced FADH₂ is a product of Complex II with downstream electron flow from CII to Q."

Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002