Miller 2006 FEBS Lett: Difference between revisions
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{{Publication | {{Publication | ||
|title=Miller I, Gemeiner M, Gesslbauer B, Kungl A, Piskernik C, Haindl S, NΓΌrnberger S, Bahrami S, Redl H, Kozlov AV (2006) Proteome analysis of rat liver mitochondria reveals a possible compensatory response to endotoxic shock. FEBS | |title=Miller I, Gemeiner M, Gesslbauer B, Kungl A, Piskernik C, Haindl S, NΓΌrnberger S, Bahrami S, Redl H, Kozlov AV (2006) Proteome analysis of rat liver mitochondria reveals a possible compensatory response to endotoxic shock. FEBS Let 580: 1257-1262. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/16442530 PMID: 16442530] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/16442530 PMID: 16442530] | ||
|authors=Miller I, Gemeiner M, Gesslbauer B, Kungl A, Piskernik C, Haindl S, Nuernberger S,Β Bahrami S, Redl H, Kozlov AV | |authors=Miller I, Gemeiner M, Gesslbauer B, Kungl A, Piskernik C, Haindl S, Nuernberger S,Β Bahrami S, Redl H, Kozlov AV | ||
|year=2006 | |year=2006 | ||
|journal=FEBS | |journal=FEBS Let | ||
|abstract=Organ failure induced by endotoxic shock has recently been associated with affected mitochondrial function. In this study, effects of in vivo lipopolysaccharide-challenge on protein patterns of rat liver mitochondria in treated animals versus controls were studied by two-dimensional electrophoresis (differential image gel electrophoresis). Significant upregulation was found for ATP-synthase Ξ± chain and superoxide dismutase [Mn]. Our data suggest that endotoxic shock mediated changes in the mitochondrial proteome contribute to a compensatory reaction (adaptation to endotoxic shock) rather than to a mechanism of cell damage. | |abstract=Organ failure induced by endotoxic shock has recently been associated with affected mitochondrial function. In this study, effects of ''in vivo'' lipopolysaccharide-challenge on protein patterns of rat liver mitochondria in treated animals versus controls were studied by two-dimensional electrophoresis (differential image gel electrophoresis). Significant upregulation was found for ATP-synthase Ξ± chain and superoxide dismutase [Mn]. Our data suggest that endotoxic shock mediated changes in the mitochondrial proteome contribute to a compensatory reaction (adaptation to endotoxic shock) rather than to a mechanism of cell damage. | ||
|keywords=Mitochondria, Proteomics, Lipopolysaccharide, Endotoxic shock, ATP-synthase, Superoxide dismutase | |keywords=Mitochondria, Proteomics, Lipopolysaccharide, Endotoxic shock, ATP-synthase, Superoxide dismutase | ||
|mipnetlab=AT_Vienna_Kozlov AV | |mipnetlab=AT_Vienna_Kozlov AV | ||
Revision as of 21:26, 22 June 2012
| Miller I, Gemeiner M, Gesslbauer B, Kungl A, Piskernik C, Haindl S, NΓΌrnberger S, Bahrami S, Redl H, Kozlov AV (2006) Proteome analysis of rat liver mitochondria reveals a possible compensatory response to endotoxic shock. FEBS Let 580: 1257-1262. |
Β» [[Has info::PMID: 16442530]]
Miller I, Gemeiner M, Gesslbauer B, Kungl A, Piskernik C, Haindl S, Nuernberger S, Bahrami S, Redl H, Kozlov AV (2006) FEBS Let
Abstract: [[has abstract::Organ failure induced by endotoxic shock has recently been associated with affected mitochondrial function. In this study, effects of in vivo lipopolysaccharide-challenge on protein patterns of rat liver mitochondria in treated animals versus controls were studied by two-dimensional electrophoresis (differential image gel electrophoresis). Significant upregulation was found for ATP-synthase Ξ± chain and superoxide dismutase [Mn]. Our data suggest that endotoxic shock mediated changes in the mitochondrial proteome contribute to a compensatory reaction (adaptation to endotoxic shock) rather than to a mechanism of cell damage.]] β’ Keywords: Mitochondria, Proteomics, Lipopolysaccharide, Endotoxic shock, ATP-synthase, Superoxide dismutase
β’ O2k-Network Lab: AT_Vienna_Kozlov AV
Labels:
Stress:Mitochondrial Disease; Degenerative Disease and Defect Organism: Rat Tissue;cell: Hepatocyte; Liver
Regulation: Respiration; OXPHOS; ETS Capacity
HRR: Oxygraph-2k
