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Sliwa 2012 Acta Biochim Pol

From Bioblast
Publications in the MiPMap
Sliwa A, Goralska J, Czech U, Gruca A, Polus A, Zapala B, Dembinska-Kiec A (2012) Modulation of the human preadipocyte mitochondrial activity by beta-carotene. Acta Biochim Pol 59:39-41.

» PMID: 22428124 Open Access

Sliwa A, Goralska J, Czech U, Gruca A, Polus A, Zapała B, Dembinska-Kiec A (2012) Acta Biochim Pol

Abstract: Increased ROS generation by the overload by metabolic substrates mitochondria paralleled by decrease of antioxidant activity are typical events found in metabolic syndrome and diabetes type 2. Metabolites of beta-carotene (BC) such as retinoic acid (RA), as well as low concentration of reactive oxygen species (ROS) modify the mitochondrial bioenergetic function. The aim of the study was to investigate the effect of beta-carotene on mitochondrial activity in human preadipocytes. BC used in concentrations, 10 or 30 µM, decreased mitochondrial membrane potential, inhibited mitochondrial respiration and decreased cellular ATP content. We conclude, that BC, the known antioxidant may decrease oxidative phosphorylation capacity of mitochondria. Keywords: Metabolic syndrome, diabetes, beta-carotene, retinoic acid, Chub-S7, preadipocytes

O2k-Network Lab: PL Krakow Dembinska-Kiec A


Labels: MiParea: Respiration  Pathology: Diabetes  Stress:Oxidative stress;RONS  Organism: Human  Tissue;cell: Fat  Preparation: Intact cells  Enzyme: Complex V;ATP synthase 


HRR: Oxygraph-2k