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Ping 2015 Oxid Med Cell Longev

From Bioblast
Publications in the MiPMap
Ping Z, Zhang LF, Cui YJ, Chang YM, Jiang CW, Meng ZZ, Xu P, Liu HY, Wang DY, Cao XB (2015) The protective effects of Salidroside from exhaustive exercise-induced heart injury by enhancing the PGC-1๐›ผโ€“NRF1/NRF2 pathway and mitochondrial respiratory function in rats. Oxid Med Cell Longev Article ID 876825.

ยป [1]

Ping Z, Zhang LF, Cui YJ, Chang YM, Jiang CW, Meng ZZ, Xu P, Liu HY, Wang DY, Cao XB (2015) Oxid Med Cell Longev

Abstract: To test the hypothesis that salidroside (SAL) can protect heart from exhaustive exercise-induced injury by enhancing mitochondrial respiratory function and mitochondrial biogenesis key signaling pathway PGC-1๐›ผโ€“NRF1/NRF2 in rats.

Male Sprague-Dawley rats were divided into 4 groups: sedentary (C), exhaustive exercise (EE), low-dose SAL (LS), and high-dose SAL (HS). After one-time exhaustive swimming exercise, we measured the changes in cardiomyocyte ultrastructure and cardiac marker enzymes and mitochondrial electron transport system (ETS) complexes activities in situ. We also measured mitochondrial biogenesis master regulator PGC-1๐›ผ and its downstreamtranscription factors, NRF1 and NRF2, expression at gene and protein levels.

Compared to C group, the EE group showed marked myocardium ultrastructure injury and decrease of mitochondrial respiratory function (p<0.05) and protein levels of PGC-1๐›ผ, NRF1, and NRF2 (p<0.05) but a significant increase of PGC-1๐›ผ, NRF1, and NRF2 genes levels (p<0.05); compared to EE group, SAL ameliorated myocardium injury, increased mitochondrial respiratory function (p<0.05), and elevated both gene and protein levels of PGC-1๐›ผ, NRF-1, and NRF-2.


Salidroside can protect the heart from exhaustive exercise-induced injury. It might act by improving myocardial mitochondrial respiratory function by stimulating the expression of PGC-1๐›ผโ€“NRF1/NRF2 pathway.


Labels: MiParea: Respiration, mt-Biogenesis;mt-density, mtDNA;mt-genetics, Exercise physiology;nutrition;life style 


Organism: Rat  Tissue;cell: Heart  Preparation: Permeabilized tissue 


Coupling state: OXPHOS, ET  Pathway: N, S, CIV, ROX  HRR: Oxygraph-2k