Hernandez-Hernandez 2019 Mol Biol Rep

Hernández-Hernández KL, Tapia-Orozco N, Gimeno M, Espinosa-García AM, García-García JA, Araiza-Olivera D, Sánchez-Bartez F, Gracia-Mora I, Gutierrez-Aguilar M, García-Arrazola R (2019) Exposure to bisphenol A: current levels from food intake are toxic to human cells. https://doi.org/10.1007/s11033-019-04666-1

» Mol Biol Rep 46:2555-59. PMID: 30734171

Hernandez-Hernandez Karla L, Tapia-Orozco Natalia, Gimeno Miquel, Espinosa-Garcia Ana Maria, Garcia-Garcia Jose Antonio, Araiza-Olivera Daniela, Sanchez-Bartez Francisco, Gracia-Mora Isabel, Gutierrez-Aguilar Manuel, Garcia-Arrazola Roeb (2019) Mol Biol Rep

Abstract: In the present work, cell lines of different origin were exposed to BPA levels from food intake reported elsewhere. Specifically, we used an in vitro assay to determine cytotoxicity of BPA in three cell lines: MCF7 (breast cancer), PC3 (prostate cancer) and 3T3-L1 (mouse fibroblast). Cytotoxic effects were observed at concentrations higher than 50 μg/mL which is above the involuntary exposure level of BPA described before in fresh, canned and frozen foods and beverages. Furthermore, medial inhibitory concentrations (IC50) of 85.17 μg/mL and 88.48 μg/mL were observed for PC3 and 3T3-L1, respectively, and a slightly lower IC50 of 64.67 μg/mL for MCF7. These results highlight BPA's toxicity potential at current levels from food intake. The cell line-dependent divergent response to BPA reported herein is discussed. • Keywords: Bisphenol A, Cytotoxicity, Food • Bioblast editor: Plangger M

Labels: MiParea: Pharmacology;toxicology