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Correa 2015 Critical Care Horizon

From Bioblast
Publications in the MiPMap
Corrรชa TD, Jakob SM, Takala J (2015) Mitochondrial function in sepsis. Critical Care Horizon 1:31-41 .

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Correa TD, Jakob SM, Takala J (2015) Critical Care Horizon

Abstract: Sepsis syndrome represents a leading cause of intensive care unit (ICU) admission, morbidity and mortality. Several areas within the pathophysiology of sepsis remain controversial despite extensive pre-clinical and clinical research. It has been postulated that mitochondrial dysfunction may contribute to organ dysfunction and failure in sepsis. Nevertheless, many aspects of mitochondrial malfunction and the exact mechanisms as to how it may be linked to organ dysfunction remain unknown. Here, we briefly review some basic concepts of mitochondrial function in sepsis. The main available methods to assess mitochondrial function are presented and pre-clinical and clinical work summarized to show and explain some of the main controversies surrounding the role of mitochondrial function in sepsis. Finally, we propose future directions for new research in the field. โ€ข Keywords: Sepsis, Septic shock, Mitochondria, Multiple organ failure, Animal model, Resuscitation


Labels: MiParea: Respiration  Pathology: Sepsis 

Organism: Pig  Tissue;cell: Liver  Preparation: Isolated mitochondria 


Coupling state: LEAK, OXPHOS  Pathway: N, S, CIV, ROX  HRR: Oxygraph-2k 

Review